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Den viktigste årsaken er sannsynligvis at petidinmetabolitten norpetidin akkumuleres hos barnet (fig 1). Hvis det er indikasjon for å gi sterke opioidanalgetika, bør derfor morfin foretrekkes fremfor petidin. Kodein forekommer naturlig i opiumsvalmuen, Papaver somniferum. Navnet kodein kommer fra kodeia, det greske ordet for valmuekapsel. Isole